Design, Synthesis and Antidiabetic, Cardiomyopathy Studies of Cinnamic Acid-Amino Acid Hybrid Analogs

Diabetes mellitus is a chronic metabolism disorder characterized by hyperglycemia due to insulin deficiency or insulin resistance. Associated complications include Myocardial infarction, cardiomyopathy, retinopathy, neuropathy, nephropathy, etc. Cinnamic acid analogs (SSPC0-SSPC20) containing different amino acids were designed and docked into crystal structure of AMPK and PPARs. Among the 20 designed compounds five compounds namely SSPC5, SSPC8, SSPC11, SSPC14, SSPC15 showed good docking scores using Glide 5.0 Maestro program and were subjected to ADME prediction by using software Quickprop version 3.1. These were then selected for synthesis, characterized and antidiabetic activity carried out using Alloxan induced diabetic rat model by measuring blood glucose levels using glucometer at 0, 1, 2, 4, 6, 8 and 24 hrs through the tail vein puncture method. SSPC5, SSPC8, SSPC11, SSPC14 showed % reduction in blood glucose of 23.02%, 37.02%, 14.04% and 15.96% as compared to standard with 33.53% reduction. As SSPC14 had good and comparable docking scores in both AMPK and PPAR γ receptor, so it was subjected for the Diabetic as well as diabetic cardiomyopathy activity by recording the electrocardiogram of both diabetic and control rat. It was found to be very efficient at low dose and had a prolong duration of action on the heart (Up to 54 hrs). Thus this study indicated that such hybrid antidiabetic drug with dual action on hyperglycemia and cardiac function is desirable and cost effective. *Corresponding author: Deepanwita Maji, Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, India, Tel: +919334870271; Fax: 0651-2276247; E-mail: [email protected] Received November 16, 2013; Accepted February 25, 2014; Published February 27, 2014 Citation: Prakash S, Maji D, Samanta S, Sinha RK (2014) Design, Synthesis and Antidiabetic, Cardiomyopathy Studies of Cinnamic Acid-Amino Acid Hybrid Analogs. Med chem 4: 345-350. doi:10.4172/2161-0444.1000163 Copyright: © 2014 Prakash S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.